 | George |
 | Captain Underpants |
 | Professor Poopypants |
 | Harold |
 | Melvin |
 | Edith |
 | Ms. Ribble (voice) (as Dee Dee Rescher) |
 | Mr. Rected (voice) |
Tommy (voice) | |
 | Mr. Fyde (voice) |
 | Ms. Dayken (voice) |
George's Mom (voice) | |
Sad Girl | |
Mime (voice) | |
Officer McPiggly (voice) | |
 | Goody Two-Shoes Girl (voice) |
 | Nobel Moderator (voice) |
 | Nobel Audience Member (voice) |
Balloon Girl (voice) |